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Distinguished Lecturer -- Prof. Shankar SubramaniamThe distinguished lecturer seminar will take place April 9, 2010, 3-4pm in Woodward 106. Open to the public. |
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Bioinformatics Related Seminars -- Spring 2010The Department of Bioinformatics and Genomics hosts a weekly seminar series that covers research within Bioinformatics, Genomics, and Computational Biology. Students, faculty, colleagues, and public are invited to attend. Seminars take place on Fridays at 3:30pm in the Bioinformatics Building Room 105, unless noted differently. For speaker and topic suggestions, please contact, Dr. Cynthia Gibas (cgibas at uncc.edu). If you have questions about logistics or would like to set up an appointment with a speaker, please contact Kim Davis (kwdavis at uncc.edu) |
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UNC Charlotte's Bioinformatics BuildingThe Bioinformatics Research Center is now located in the new Bioinformatics Building! All Bioinformatics courses for the Fall Semester are held in the Bioinformatics Building. See the transformation! |
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Dr. Xiaoman Li presents "Discovery of motifs and motif modules in DNA sequences" March 31, 2008Abstract: Identifying motifs and motif modules is critical to understand gene regulation. Available methods can not be readily applied to high eukaryotes because they either cannot identify motifs and motif modules in non-promoter regions, or they can not identify divergent motifs and motif modules. We have thus developed novel methods to identify motifs and motif modules in high eukaryotes. Besides, we have designed unique ways to assess the reliability of the identified motifs and motif modules. Without necessity of doing multiple alignment, our methods can not only identify motifs and motif modules on the whole genome scale, but also can detect motifs and motif modules across very distant species. Compared with existing motif and motif module identification methods, our methods show much better performance. |
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Dr. Christopher Ellis presents "In Silico: Application of a Novel Software Suite for the Study of Cold Stress Syndrome in Manatees." April 14, 2008Abstract: Manatees have been found as far west as Texas and as far North as Rhode Island during the summer months however, the vast majority are found in southern Florida year round. Florida Fish and Wildlife calculates the number of mature manatees at only 2,181 and were until recently listed as an endangered species. During the winter manatees seek warm water refuges such as natural springs and power plant discharges. However, they must leave these warm environments to forage for food in the colder water, causing significant stress and potentially death to the animal. Symptoms of a cold stressed manatee can include but are not limited to white skin around the face, flippers and tail and/or deep grooves on the underside from the animal using significant amounts of their fat stores in order to keep warm. Rapid human population growth in Florida and associated water demand has resulted in the destruction natural spring flows in which the manatees rely on for warmth during the winter. Manatees are reliant on the microbial communities in their digest tract not only for nutrients but also buoyancy and warmth. We examined the microbial population of a healthy manatee and contrasted it with the microbial community associated with a cold stressed manatee sampling from the proximal intestine, distal intestine, and mid large intestine of both animals. Significant and important microbial shifts were seen in all three locations, including the emergence of opportunistic pathogens in the cold stressed manatee. This new insight on manatee health is being used by the Florida Fish and Wildlife in an effort to restore cold stressed manatees to health. |
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Dr. Sunil Hwang presents "Biomarker Discovery by Mass Spectrometry and Bioinformatics" April 25, 2008Biomarker detection is dependent upon the dynamic range of the sample of interest. The dynamic range of a typical clinical sample, usually tissue or blood, varies from six to twelve orders of magnitude. Our research has been applied to the optimization of methodologies, including protein preparation, separation, and data analysis, utilized in the identification of early stage disease biomarkers. Proteomics represents the combination of three disciplines: Biology, Mass Spectrometry, and Bioinformatics. Due to the complexity and volume of data generated by proteomics applications, the demands for bioinformatics approaches to data analysis are ever increasing. Using these experimental strategies and bioinformatics tools we have been able to elucidate the global proteome profile for the Jurkat T cell line, determine the feasibility of direct protein sequencing from minute tissue section samples, and establish depletion strategies for removal of the highly abundant proteins found in serum/plasma. Our future goals include improving and streamlining the bioinformatics aspects associated with proteomic research and biomarker discovery. |
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Dr. Mark Wilson presents "The role of phylogenetic analysis in forensic DNA typing" April 18, 2008Abstract: Uniparentally inherited genetic loci, such as mitochondrial DNA and the Y-chromosome, are inherited as a single genetic locus; mtDNA from the maternal line and the Y chromosome from the parental line. These markers are a valuable aspect of forensic DNA typing, and offer the analyst information not easily discerned from the current set of autosomal STRs. Because of their status as single genetic loci, the statistical power of these markers in forming weight assessments is greatly reduced, and hence these markers must be treated differently in this respect than commonly used autosomal markers. The tool of phylogenetic analysis can assist in the proper interpretation of uniparentally inherited markers and is therefore an important tool of the modern forensic laboratory. |
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Bioinformatics Seminar Series: Fall 2008The Bioinformatics Seminars are generally every Friday at 2pm in Cameron Research Center Room 101. They are open to the public. The seminars are sponsored by the Bioinformatics Research Center and Charlotte Research Center. |
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Bioinformatics Seminar (PhD Student Rotation Talks)--December 12, 1:30pm, CHHS 155Second half of PhD students rotation talks. Jon McCafferty will discuss "Systematic analysis of indels in highly homologous protein structures". His rotation Supervisor was Dr. Jun-tao Guo. Following Jon, Minli Xu will present. Minli will present "A survey of hydrogen bind network conservation within homologous proteins". Minli's rotation supervisor was Dr. Dennis Livesay. Following Minli will be Charles David. Charles, supervised by Dr. Don Jacobs, will present "Investigating flexibility in proteins using Framework Rigidity Optimized Dynamics Algorithm". Pizza lunch will be sponsored by VWR prior seminar at 1:30. |
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First Bioinformatics and Genomics Retreat a SuccessOutside the glass encased hallway, it was cold and rainy in Charlotte, but inside the energy levels were high and enthusiasm hot as more than 200 scientists from industry and academia met at UNC-Charlotte's Center for Bioinformatics and Genomic's first Bioinformatics and Genomics retreat this afternoon. |
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Bioinformatics and Genomics Retreat Day Announcement: December 10, 2008The New Department of Bioinformatics and Genomics (as of October 2008) invites you to the first ever Bioinformatics & Genomics Retreat, DECEMBER 10, 2008 (Reading Day) at 2pm in Grigg Hall on the CRI Research and Technology Campus. |
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Bioinformatics Seminar (PhD Student Rotation Talks)--December 5, 2pm, CHHS 155PhD students will talk 20 minutes about their rotation talks. Deeptak Verma wil discuss "Predicting mutant stability with a combined experimental/theoretical approach". His rotation Supervisor was Dr. Don Jacobs. Following Deeptak, Shan Li will present her rotation project with Dr. Xintao Wuo. Following Shan will be Cristina Baciu. Cristina will present "Direct Comparison Between mDCM Model and an Associated Gò-like Model". Cristina's rotation supervisor was Dr. Dennis Livesay. |
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Applications of the Roche/454 FLX Genome SequencerNovember 21, 2pm -- Dr. Joe Jones (University of South Carolina, Columbia) states that the field of biology has been significantly altered by new technology in the field of DNA sequencing. From the first DNA sequences in 1977 to the com- pleted human genome in 2003, the overwhelming majority of DNA sequence data was obtained using the identical chemistry (i.e., di-deoxy termination). Staring in 2005, a novel means of sequencing DNA via emulsion PCR (emPCR) and pyrosequencing was introduced that allowed a quantum leap in the ability to sequence genomes and survey genetic variation. This talk will cover the methodologies and principles behind emPCR, pyrosequencing, and how the combination of these two techniques can be applied to a variety of biological topics. |
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Computational and Experimental Approaches to Modeling Gene RegulationNovember 14, 3pm -- Dr. Gary Stormo, Distinguished Bioinformatics Lecturer will discuss one of the challenges of genomics research which is to understand the regulation of gene expression. Much of the regulation is controlled through DNA-protein interactions and we have been developing tools, both computational and experimental, to study those interactions for many years. This talk will outline some of the approaches we have been using and how they inform us about the regulatory network that governs the cell's behavior. Post-transcriptional regulation also plays a role in controlling gene expression, and some of our work on that topic will also be described. |
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Bioinformatics Seminar -- Nov 7, Surface plasmon resonance spectroscopy measurements of DNA/DNA, DNA/drug and protein/protein bindingNovember 7, 2pm -- Dr. Rosina Georgiadis (Chemistry Department, Boston University) will review the fundamentals of SPR as well as describe techniques developed in my laboratory such as two-color SPR and angle-scanning SPR imaging. She will discuss what we have learned about DNA/DNA hybridization kinetics at interfaces from careful measurements as a function of probe density, secondary structure and composition (mismatch) as well as comparative kinetic measurements in solution (obtained by UV-vis absorption spectroscopy). She will also present more recent work on protein/protein interactions and future directions. |
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Bioinformatics Seminar -- October 31, 2pm, CARC 101Jean-Luc Mougeot, Ph.D. Senior Scientist Carolinas Medical Center |
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2008 Charlotte Biotechnology Conference: October 28, 2008The 7th Annual Charlotte Biotechnology Conference will provide insight from some of the most recognized biotechnology, business and research professionals from around the globe in addition to highlighting regional opportunities and investment trends within the local biotechnology sector. |
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Bioinformatics Seminar -- October 24, 2pm, CARC 101Dr. Sudhir Kumar, Director: Center for Evolutionary Functional Genomics and Professor of Life Sciences, Arizona State University |
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Bioinformatics Seminar -- October 17, 2pmGuojun Li, PhD Senior Research Scientist Computational System Biology Laboratory Department of Biochemistry and Molecular Biology Endowed Professor of Mathematics and System Sciences University of Georgia |
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Bioinformatics Seminar -- October 10, 2pmDebra T. Burhans, PhD, Associate Professor, Computer Science, Department Co-Chair of CS, Director of Bioinformatics, Canisius College |
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Bioinformatics Seminar -- October 3, 2pmJacquelyn S. Fetrow, PhD Wake Forest University, Reynolds Professor of Computational Biophysics, Director, Graduate Track in Structural and Computational Biophysics, Departments of Computer Science and Physics |
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Bioinformatics Seminar -- September 26, 2pmDr. Gabriel del Rio - National Autonomous University of Mexico |
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Bioinformatics Seminar -- September 19, CARC 101 2:00pmSaurabh Sinha, PhD, Assistant Professor, Computer Science, Affiliated Faculty, Institute for Genomic Biology, University of Illinois at Urbana-Champaign |
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Bioinformatics Seminar -- September 12, CARC 101 2:00pmNICHOLAS J. PROVART, Ph.D., Department of Cell and Systems Biology, University of Toronto, Toronto, ON. CANADA |
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Updated* Bioinformatics Orientation -- August 29, 1:30pmBioinformatics Orientation: All Bioinformatics students are required to attend. Everyone involved with BRC is encouraged to attend. |
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Ahead-of-the-Curve CareersU.S. News & World Report Career Guide 2008: Here’s a look at a dozen cutting-edge careers, viable now and poised for future growth. They stem from megatrends like globalization, digitization, and the wave of environmentalism sweeping the world. Ahead-of-the-Curve Overview: Asian Business Development Specialist, Behavioral Geneticist, Computational Biologist, Data Miner, Emergency Planning Manager, Green-Collar Consultant, Health Informatics Specialist, Immigration Specialist, Offshoring Manager, Patient Advocate, Simulation Developer, & Wellness Coach |
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NCRCOn Monday, September 12, 2005, David H. Murdock, owner of Castle & Cooke, Inc. and Dole Food Company, Inc., and Molly Corbett Broad, president of the 16-campus University of North Carolina, unveiled plans for the North Carolina Research Campus, a massive scientific and economic revitalization project that encompasses the former Cannon Mills plant and entire downtown area of Kannapolis, North Carolina. |
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Dr. David Page presents "Machine Learning in the Analysis of Mass Spectrometry Data" April 11, 2008This talk will discuss three applications of machine learning to mass spectrometry data. It will begin with the task of building diagnostic models from mass spec proteomics data for organisms whose proteomes are not known (whose genomes have not been sequenced). It will use the example of studying prion infection in a hamster model. Second, the talk will examine the task of identifying the isotopic distributions in a spectrum; this task has applications to both mass spec proteomics and metabolomics. It will then apply this approach to the third task, that of quantifying the amounts of various proteins in a sample based on isotopic labeling, in this particular case, metabolic labeling. |
